5-(Trifluoromethyl)pyridin-2-carboxamide oxime

5-(Trifluoromethyl)pyridin-2-carboxamide oxime - Names and Identifiers

Name	5-(Trifluoromethyl)pyridine-2-carboxamide oxime
Synonyms	5-(Trifluoromethyl)-ALPHA-picolinamide 5-(Trifluoromethyl)pyridin-2-ylamidoxime N-Hydroxy-5-(trifluoroMethyl)picoliniMidaMide 5-(Trifluoromethyl)pyridin-2-carboxamide oxime 5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE OXIME 5-(Trifluoromethyl)pyridine-2-carboxamide oxime (Z)-N'-hydroxy-5-(trifluoroMethyl)picoliniMidaMide N-hydroxy-5-(trifluoromethyl)-2-Pyridinecarboximidamide N-hydroxy-5-(trifluoromethyl)pyridine-2-carboximidamide N'-hydroxy-5-(trifluoromethyl)pyridine-2-carboximidamide
CAS	175277-44-8
EINECS	604-604-1
InChI	InChI=1/C7H6F3N3O/c8-7(9,10)4-1-2-5(12-3-4)6(11)13-14/h1-3,14H,(H2,11,13)

5-(Trifluoromethyl)pyridin-2-carboxamide oxime - Physico-chemical Properties

Molecular Formula	C7H6F3N3O
Molar Mass	205.14
Density	1.527g/cm³
Melting Point	124-126°C
Boling Point	328.112°C at 760 mmHg
Flash Point	152.237°C
Vapor Presure	0mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.527

5-(Trifluoromethyl)pyridin-2-carboxamide oxime - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Class	IRRITANT

5-(Trifluoromethyl)pyridin-2-carboxamide oxime - Introduction

5-(Trifluoromethyl)pyridine-2-carboxamide oxime, chemical formula C7H4F3N3O, molecular weight of 191.12g/mol. It is a solid powder, colorless or light yellow, with a pungent odor.

The compound has certain toxicity and corrosiveness, so personal protective measures should be paid attention to during use. Avoid direct contact with skin, eyes and respiratory tract. In case of contact, rinse immediately with clean water and seek medical assistance.

5-(Trifluoromethyl)pyridine-2-carboxamide oxime is mainly used as catalysts and intermediates in organic synthesis. It is often used in chemical processes for the reduction of aromatic aldehydes and ketones or the reduction of halogenated acidification products. In addition, it can also be used as a protecting group removing agent in organic synthesis for removing the p-hydroxyl protecting group.

The preparation method of the compound can be obtained by reacting 5-aminopyridine with trifluoroformaldehyde. The 5-aminopyridine is first dissolved in a suitable solvent and then the trifluoroformaldehyde solution is slowly added dropwise. At the end of the reaction, the product is isolated by crystallization or other isolation methods.

Finally, it should be emphasized that for the use of any chemical, the operating procedures and safety operation manuals must be strictly followed to ensure the safety and effectiveness of use. When chemicals are used in laboratory or industrial environments, adequate risk assessments should be conducted in advance and appropriate safety measures should be taken, such as wearing chemical protective gloves, goggles and protective clothing.

Last Update：2024-04-10 22:29:15